Eidetic Analysis of the Premature Chromosome Condensation Process
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چکیده
منابع مشابه
Induction of premature chromosome condensation (PCC) by calyculin A for biodosimetry
Background: Premature chromosome condensation (PCC) is a method for interphase chromosome analysis in biodosimetry. This study was performed to verify the usefulness of PCC induced by calyculin A in human peripheral blood lymphocytes (pbl) for biological dosimetry and possible construction of dose-response curve. Materials and Methods: Peripheral blood was obtained from a healthy donor and expo...
متن کاملConstruction of a dose – response curve by induction of premature chromosome condensation for biological dosimetry
Premature Chromosome Condensation (PCC) appears to have a possible utility for biological dosimetry purposes. The PCC technique may be adapted for cases of suspicion of overexposure where sampling is performed at least one day after an accident. For this purpose, human blood samples were exposed in vitro to 60Co up to 10 Gy and the PCC technique was performed immediately after irradiation. Anal...
متن کاملBiological Dose Assessment by Chemical Induction of Premature Chromosome Condensation
Dose assessment of radiation victims is a key element in medical management of radiation accidents. At high radiation doses (> 6 Gy), dicentric assay lose its efficiency and premature chromosome condensation (PCC) assay was proposed to overcome the restrictions of dicentric assay. It was shown that PCC ring is more suitable and simpler than dicentric for biodosimetry in high radiation doses. In...
متن کاملAnalysis of interphase chromosome damage by means of premature chromosome condensation after X- and ultraviolet-irradiation.
Sendai virus-mediated fusion between mitotic and interphase mammalian cells causes the rapid condensation of the interphase chromosomes into distinct structures, a process termed premature chromosome condensation. This phenomenon has been used to assess the immediate action of x-rays and ultraviolet light on the chromosomes of HeLa cells irradiated in the G1 phase of the life cycle. X-irradiati...
متن کاملEffect of Protamine Deficiency on Fertilization Outcome and Incidence of Sperm Premature Chromosomal Condensation Post ICSI
Purpose: After aneuploidy,sperm premature chromatin condensation (PCC) is the next most important cause of fertilization failure. Therefore the aim of this study is to evaluate the effect of sperm protamine deficiency on sperm PCC formation post ICSI. Materials and Methods: Cytogenetic analysis was carried out on unfertilized oocytes post ICSI and incidence of sperm PCC was evaluated. The resu...
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تاریخ انتشار 2017